Orbitrap Illustration

Targeted Screening & Quantitation

Ensuring the safety of the world’s food supply is of utmost importance. Screening foodstuffs for known and unknown contaminants, such as pesticides, herbicides, antibiotics, and adulterated food, must be quick and simple, but identifying these contaminants is a challenging experiment.  Analysis by mass spectrometry with high resolution and accurate mass is ideally suited for food sample screening and quantification of hundreds to thousands of contaminants in a single analysis. Orbitrap™-based mass spectrometers provide high-resolution, accurate-mass (HR/AM) capabilities with fast scanning speeds required to deliver results quickly to quarantine contaminated food and ensure only safe food is brought to the market. 

For additional resources, search the Orbitrap Science Library

Workflow Overview for Targeted Screening & Quantitation of Food Contaminants

For targeted screening of food, samples are collected and sent to a food testing lab where they are  logged into the system.  The targeted screening of contaminates is performed using variations of the workflow described here.  Samples are processed and contaminants are extracted using various methods from QuEChERS and offline SPE and then analyzed on the mass spectrometer. Data is scrutinized and the amount of contaminate is determined using automated software, and the results are verified by the scientist.  The goal of a targeted approach is to determine if the contaminate is present, and if it is, how much is present in the sample.


Comprehensive qualitative and quantitative determination of pesticides and veterinary drugs in honey using liquid chromatography–Orbitrap high resolution mass spectrometry

Gómez-Pérez ML, Plaza-Bolaños P, et al.
J Chromatogr A. 2012 Jul 27;1248:130-8.

Food contaminant analysis at ultra-high mass resolution: application of hybrid linear ion trap - orbitrap mass spectrometry for the determination of the polyether toxins, azaspiracids, in shellfish

Skrabáková Z, O'Halloran J, et al.
Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):2966-74.

Effects of milling and baking technologies on levels of deoxynivalenol and its masked form deoxynivalenol-3-glucoside

Kostelanska M, Dzuman Z, et al.
J Agric Food Chem. 2011 Sep 14;59(17):9303-12.