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Scientific Poster Orbitrap Fusion Lumos PPCC - Hydrogen-Deuterium Exchange

20S Proteasome Conformational Dynamics Study by HDX-MS

Shaunak Raval1, Vlad Sarpe2, Terry Zhang3, Rosa Viner3, Albert Konijnenberg4, Andreas Huhmer3, David C. Schriemer1,2

Hupo 2019

1Department of Chemistry, 2Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada Thermo Fisher Scientific, 3San Jose, US, 4Eindhoven, The Netherlands

Purpose: - Study the conformational changes accompanying the in-vitro activation of 20S proteasome catalytic activity in the presence of low concentration of SDS

Methods: HDX-MS was used to study the perturbation of conformational dynamics of Rabbit 20S proteasome complex in the…

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