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Scientific Poster Orbitrap Fusion Lumos, Q Exactive UHMR Bottom-up Proteomics, PTM - Other, Top-Down Proteomics, Intact Protein Characterization, PPCC - Cross Linking, PPCC - Native

Integrative Structural Proteomics Analysis of the 20S Proteasome Complex

Rosa Viner1; David M. Horn1; Eugen Damoc2; Albert Konijnenberg3

IMSC 2018

1Thermo Fisher Scientific, San Jose, CA 2Thermo Fisher Scientific, Bremen, Germany 3Thermo Fisher Scientific, Eindhoven, Netherlands

Introduction: The structural determination of protein complexes plays an important role in the fundamental understanding of their catalytic function. Multiple analytical methods, including hybrid approaches such as cryoelectron microscopy, crosslinking, and native mass spectrometry, are…

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