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Scientific Poster Q Exactive HF Bottom Up Protein Characterization, Intact Antibody Characterization

Full Characterization of Heterogeneous Antibody Samples Under Denaturing and Native Conditions on a Hybrid Quadrupole-Orbitrap Mass Spectrometer

Scheffler K, Damoc E, Sutton J, Bailey A, Houel S, Josephs J.

ASMS 2016 Poster

Thermo Fisher Scientific

Here we cover the three major workflows for characterization of biopharmaceuticals on one single instrument LC-MS platform using single and mixed antibody samples: 1)intact mass analysis, 2) subunit analysis and 3) peptide mapping - aiming at confirming antibody sequences and disulfide…

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