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Scientific Poster Orbitrap Exploris 480 SureQuant Quantitation

Toward a Single Comprehensive Assay for Protein Expression of the Human Kinome

Robert Sprung1, Aaron Gajadhar2a, Michael East3, Petra Gilmore1, Daniel Lopez Ferrer2a, Bhavin Patel2b, Sebastien Gallien2c, Dennis Goldfarb1, Ben Major1, Gary L. Johnson3, R. Reid Townsend1

International Hupo 2020

1Washington University School of Medicine, St. Louis, MO 63110 2aThermo Fisher Scientific, San Jose, CA; 2bRockford, IL; 2cParis, France. 3University of North Carolina School of Medicine, Chapel Hill, NC 27599

The human kinome is comprised of 518 protein and lipid kinases which play a fundamental role in the propagation and integration of cell signaling events. Dysregulation of kinase expression and activity plays a critical role in human disease with >55 kinase inhibitors in the clinic or…

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