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Scientific Poster Orbitrap Eclipse, Q Exactive HF SureQuant Quantitation

SureQuant targeted MS workflow for Quantitative analysis of Ras and AKT signaling pathways

Penny Jensen1, Bhavin Patel1, Aaron S. Gajadhar2, Sebastien Gallien3,4, Andreas Huhmer2, Daniel Lopez-Ferrer2, Kay Opperman1, John C. Rogers

International Hupo 2020

1Thermo Fisher Scientific, Rockford, IL 2Thermo Fisher Scientific, San Jose, CA 3Thermo Fisher Scientific, PMSC, Cambridge, MA 4Thermo Fisher Scientific, Paris, France.


The RAS/MAPK and AKT/mTOR pathways represent key mechanisms for cells to regulate cell survival, proliferation, and motility. The cross-talk between two pathways plays a central role in tumor progression and anti-cancer drug resistance. The quantitation of pathway protein expression and…

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