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Scientific Paper Exactive Plus EMR Intact Antibody Characterization

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

Rosati S, Rose RJ, Thompson NJ, van Duijn E, Damoc E, Denisov E, Makarov A, Heck AJ.

Angew Chem Int Ed Engl. 2012 Nov 22.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre and Utrecht Institute of Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH (The Netherlands) bioms.chem.uu.nl.

Antibody profiling: Native mass spectrometry analysis of intact antibodies can be achieved with improved speed, sensitivity, and mass resolution by using a modified orbitrap instrument. Complex mixtures of monoclonal antibodies can be resolved and their glycan "fingerprints" can be…

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