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Scientific Poster Exactive Discovery Quan/Qual Screening

A Novel High Throughput Method Using Full Scan HRAM and Online Extraction for Plasma Protein Binding Determination

Cook K, Dreyer M, Murphy K.

Scientific Poster

Thermo Fisher Scientific


Purpose: Plasma protein binding determination.

Methods: Rapid equilibrium dialysis, HRAM, and online extraction.

Results:Protein binding determination was conducted in both human and rat plasma for a wide spectrum of low to high binding compounds such as Gabapentin (literature…

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