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Scientific Paper Exactive Plus EMR Intact Antibody Characterization, PTM - Glycosylation

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap.

Rosati S, van den Bremer ET, Schuurman J, Parren PW, Kamerling JP, Heck AJ.

MAbs. 2013 Aug 28;5(6).

Biomolecular Mass Spectrometry and Proteomics; Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences; Utrecht University; Utrecht, The Netherlands; Netherlands Proteomics Center; Utrecht, The Netherlands.

Here, we describe a fast, easy-to-use, and sensitive method to profile in-depth structural micro-heterogeneity, including intricate N-glycosylation profiles, of monoclonal antibodies at the native intact protein level by means of mass spectrometry using a recently introduced modified…

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