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Scientific Poster Orbitrap Fusion PPCC - Cross Linking

An optimized enrichment strategy for improved mass spec analysis of chemically crosslinked peptides

Leigh Foster1, Ryan Bomgarden1, Erum Raja1, Chris Etienne1, Rosa Viner2, John Rogers1

ASMS 2018

1Thermo Fisher Scientific, Rockford, IL; 2Thermo Fisher Scientific, San Jose, CA

Purpose: To optimize the sample preparation and enrichment workflow using an azide-tagged, acid-cleavable disuccinimidyl bis-sulfoxide (aaDSBSO) crosslinker for studying protein-protein interactions.

Methods: Amine-reactive, MS-cleavable crosslinkers including DSSO and aaDSBSO were…

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