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Scientific Paper Orbitrap Fusion, Orbitrap Fusion Lumos RQ - TMT

A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization

Brian K. Erickson, Christopher M. Rose, Craig R. Braun, Alison R. Erickson, Jeffrey Knott, Graeme C. McAlister, Martin Wühr, Joao A. Paulo, Robert A. Everley, Steven P. Gygi

Mol Cell. 2017 Jan 19;65(2):361-370. doi: 10.1016/j.molcel.2016.12.005. Epub 2017 Jan 5.

Harvard Medical School


Targeted mass spectrometry assays for protein quantitation monitor peptide surrogates, which are easily multiplexed to target many peptides in a single assay. However, these assays have generally not taken advantage of sample multiplexing, which allows up to ten analyses to occur in…

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