Orbitrap Illustration

Scientific Library

Access peer-reviewed scientific papers, application notes, technical guides, specification sheets, scientific posters, brochures, product support bulletins, webinars, and much more....


Please set up alerts based on your interests for notification of new content added by our scientists.


Remember, you must  register on the site and login to your account to see search results. 

Expand Results
Format
Product
Application
Title
Views
Application Note Q Exactive Plus Intact Antibody Characterization, BIOPHARMACEUTICALS - ALL

Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping

Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs

APPLICATION NOTE 72511

1 Thermo Fisher Scientific 1 San Jose, CA, USA 2 Dreieich, Germany 3 Bremen, Germany


To perform complete characterization of the lysine-linked antibody drug conjugate (ADC) trastuzumab emtansine using both intact mass and peptide mapping approaches with a single benchtop mass spectrometer. Critical quality attribute (CQA) measurements include drug-to-antibody ratio (DAR)…

Read more... Download file Email This Item

97
Number of Views