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Scientific Poster Orbitrap Fusion Lumos Top-Down Proteomics

In-Depth Characterization of Intact Protein Standards Using HRAM Top Down Mass Spectrometry with Multiple MSMS Strategies

Helene Cardasis1, Romain Huguet1, Chris Mullen1, Stephane Houel1, Luca Forneli2, Rosa Viner1, Viktorija Vitkovske1, Shanhua Lin1, Seema Sharma1, Vlad Zabrouskov1, Neil Kelleher2

ASMS 2017 Poster

1 – Thermo Fisher Scientific, San Jose, CA USA 2 – Northwestern University, Chicago, IL USA


Purpose: Demonstrate unique characteristics and effectiveness of various dissociation mechanisms for intact protein identification and characterization.

Methods: Collection and analysis of high resolution CID, HCD, ETD, and UVPD data on various proteins at various energies or reaction…

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