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Scientific Poster Orbitrap Fusion Lumos Top-Down Proteomics

Fast Characterization Of The Proteoform Landscape In Human Tears Using Top Down Mass Spectrometry With Multiple MS/MS Strategies

Daniel Lopez-Ferrer1, Romain Huguet1, Ioanna Ntai1, David Horn1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3

ASMS 2017 Poster

1 Thermo Fisher Scientific, San Jose, California, USA 2 Miró Center for Oculoplastic Surgery, Geel, Belgium 3 ProteoFormiX, Beerse, Belgium.

Purpose: Demonstrate the potential of top-down proteomics for mapping the proteoform diversity in the tear fluid. The proposed research workflow includes the use of Schirmer Tear Test strips (Clement Clarke International, Harlow UK) for sample collection, sample handling, and protein…

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