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Scientific Paper Orbitrap Elite Top-Down Proteomics

Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer

Luca Fornelli a,1 , Daniel Ayoub a,2 , Konstantin Aizikov b , Xiaowen Liu c,d , Eugen Damoc b , Pavel A. Pevzner e , Alexander Makarov b , Alain Beck f , Yury O. Tsybin a,g, ⁎

Journal of Proteomics Available online 27 February 2017

a Biomolecular Mass Spectrometry Laboratory, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland b Thermo Fisher Scientific GmbH, 28199 Bremen, Germany c Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, 46202 Indianapolis, IN, USA d Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 46202 Indianapolis, IN, USA e Department of Computer Science and Engineering, University of California in San Diego, 92093 San Diego, CA, USA f Centre d'Immunologie Pierre Fabre, 74160 St Julien-en-Genevois, France g Spectroswiss Sàrl, EPFL Innovation Park, 1015 Lausanne, Switzerland

The increasing importance of immunoglobulins G (IgGs) as biotherapeutics calls for improved structural characterization methods designed for these large (~ 150 kDa) macromolecules. Analysis workflows have to be rapid, robust, and require minimal sample preparation. In a previous work we…

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