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Scientific Paper Q Exactive HF RQ - Label-Free

Proteomics reveals the effects of sustained weightloss on the human plasma proteome

Philipp E Geyer, Nicolai J Wewer Albrechtsen, Stefka Tyanova, Niklas Grassl, Eva W Iepsen, Julie Lundgren, Sten Madsbad, Jens J Holst, Signe S Torekov and Matthias Mann

1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany 2NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 4NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 5Department of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark


Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill-defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss…

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