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Scientific Paper Q Exactive HF Top-Down Proteomics

Advancing top-down analysis of the human proteome using a benchtop quadrupole-Orbitrap mass spectrometer

Luca Fornelli, Kenneth Robert Durbin, Ryan T. Fellers, Bryan P. Early, Joseph B. Greer, Richard D. LeDuc, Philip D. Compton, and Neil L. Kelleher

Departments of Chemistry and Molecular Biosciences, Northwestern University, 2170 Campus Drive, Evanston, Illinois 60208


Over the past decade, developments in high resolution mass spectrometry have enabled the high throughput analysis of intact proteins from complex proteomes, leading to the identification of thousands of proteoforms. Several previous reports on top-down proteomics (TDP) relied on hybrid…

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143
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Scientific Paper LTQ Orbitrap PTM - Glycosylation, PTM - Phosphorylation

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis

Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD, Shabanowitz J, Hunt DF, Hart GW.

Sci Signal. 2010 Jan 12;3(104):ra2.

Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.


Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins. Overexpression of the enzyme that adds O-GlcNAc to target proteins, O-GlcNAc…

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25
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