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Poster Note Q Exactive Plus, Q Exactive HF Bottom Up Protein Characterization, Intact Antibody Characterization

Complete Characterization of a Cysteine-linked Antibody-Drug Conjugate Performed on a Hybrid Quadrupole-Orbitrap Mass Spectrometer with High Mass Range

Bailey A, Damoc E, Houel S, Scheffler K, Josephs J.

ASMS 2016 Poster

Thermo Fisher Scientific


We have modified the instrument control software of a benchtop quadrupole-Orbitrap mass spectrometer to add native MS capability. In this study we demonstrate complete characterization of Brentuximab vedotin, a cysteine-linked ADC, which requires native MS conditions for intact analysis.…

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