Orbitrap Illustration

Scientific Library

Access peer-reviewed scientific papers, application notes, technical guides, specification sheets, scientific posters, brochures, product support bulletins, webinars, and much more....


Please set up alerts based on your interests for notification of new content added by our scientists.


Remember, you must  register on the site and login to your account to see search results. 

Expand Results
Format
Product
Application
Title
Views
Scientific Paper Exactive Plus EMR Intact Antibody Characterization, PTM - Glycosylation

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap.

Rosati S, van den Bremer ET, Schuurman J, Parren PW, Kamerling JP, Heck AJ.

MAbs. 2013 Aug 28;5(6).

Biomolecular Mass Spectrometry and Proteomics; Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences; Utrecht University; Utrecht, The Netherlands; Netherlands Proteomics Center; Utrecht, The Netherlands.


Here, we describe a fast, easy-to-use, and sensitive method to profile in-depth structural micro-heterogeneity, including intricate N-glycosylation profiles, of monoclonal antibodies at the native intact protein level by means of mass spectrometry using a recently introduced modified…

Read more... Link to related website Email This Item

57
Number of Views