Orbitrap Illustration

Exactive Plus EMR

While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. With the optional extended mass range (EMR) of up to m/z 20,000 and improved detection of high-mass ions, the Thermo Scientific™ Exactive™ Plus EMR mass spectrometer is an outstanding platform for biopharmaceutical and biological research requiring analysis of monoclonal antibodies, antibody drug conjugates, protein assemblies, and other proteins in their native states. Combining unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with the extended mass range option, the Exactive Plus EMR MS is an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.

The Exactive Plus EMR system retains all of the capabilities that make an Exactive Plus mass spectrometer a superb tool for compound identification and high-throughput, high-performance screening for targets such as impurities in monoclonal antibodies, antibody-drug conjugates (ADC), PEG-ylated proteins, oligomerized protein-based drugs, glycoforms, and protein assemblies.


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