Orbitrap Illustration

Orbitrap Fusion Lumos EASY-IC

Most Advanced Mass Spectrometer for the Most Advanced Research Applications


Excel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. This system incorporates the brightest ion source, a segmented quadrupole mass filter with improved selectivity and ion transmission, Advanced Vacuum Technology for improved ion transmission to the Thermo Scientific™ Orbitrap™ mass analyzer, and ETD HD, a higher-capacity ETD fragmentation.

The latest innovations include the Advanced Peak Determination (APD) algorithm for improved data-dependent experiments and two new hardware options: UVPD, a new fragmentation technique achieved with a 213 nm UV laser and 1M, which provides 1,000,000 FWHM ultra-high resolution for improved structural elucidation and quantitation of isobaric compounds.


Check out the latest innovations in Orbitrap Fusion Lumos Technology:


  • EASY-IC option for improved mass-to-charge ratio (m/z) assignment

  • EASY-ETD option to efficiently fragment peptides and proteins

  • UVPD option to fragment the most challenging compounds

  • 1,000,000 FWHM ultra-high resolution for in-depth characterization

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Overview of the EASY-IC Option

Superior mass accuracy in every scan



An Orbitrap Fusion Lumos MS with the Internal Calibration configuration significantly improves the mass-to-charge ratio (m/z) assignment accuracy to less than 1 ppm*. It incorporates a second ion source (RIS), which is located in the API source interface just after the electrodynamic ion funnel. The RIS delivers a regulated number of calibrant ions into the much larger population of analyte ions. The location of the RIS allows the quadrupole mass filter to isolate the internal calibrant (reference) ions. The instrument software uses the precisely known mass-to-charge ratio of the calibration mass peak to provide real-time fine adjustment of the instrument's mass-to-charge ratio calibration, enabling a correction for otherwise uncompensated errors that are due to temperature changes and scan-to-scan variations in the total charge of the ion population analyzed.

*Under defined conditions.