Driven by decades of innovation in instrumentation and methods, the pace of progress continues to accelerate as we expand our exploration of the inner workings of the cell. New methods for comprehensive proteome analysis, rapid and efficient quantification, and characterization at the intact or digest level are revolutionizing our understanding of protein structure, dynamics and interactions. These same advances are providing us with insights into the glycome, the main class of post translational modification that brings functional diversity to the proteins. In parallel, advances in separation, instrumentation and methodology are allowing us to differentiate and quantify, with certainty, metabolite and lipid products of metabolism. The rapid expansion of our knowledge of the proteome, glycome, lipidome and metabolome is giving us a better picture of the inner working of biology and is important for understanding disease phenotypes which may lead to breakthroughs in medicine. While challenges remain in developing new MS-based technologies with increased speed, sensitivity and resolution, plus software and informatics to manage, mine, and link an enormous volume of proteomics and metabolomics information, the future remains very bright indeed. At Thermo Fisher Scientific, we are a committed partner in evolving the tools and working closely with the research community to continue this important work. Making progress not only requires the use of new high-performance tools and reagents, but also the critical innovations and passions of leading investigators who deploy them in their research. As such, in the 2013 “Globalomics” calendar, we would like to recognize and applaud the efforts of some of the very best.