Orbitrap Illustration

BioPharma Finder


 

Thermo Scientific BioPharma™ Finder™ software provides accurate characterization of biologics and uses multidimensional dynamic search capabilities to automatically reduce complex data into a concise and informative report. With this new integrated software for characterization of BioTherapeutics, confidence in the results is increased while significantly reducing the data analysis time.

Intact Protein Analysis

  • Molecule Weight Confirmation
  • Glycoform/ADC quantification
  • Top Down MS/MS (ProSight PC)

Structural Analysis

  • Disulfide mapping
  • Native MS


Peptide Mapping

  • Peptide sequence
  • PTM quantification
  • Glycopeptide ID

Software Overview for BioPharma Finder


BioPharma Finders intact workflows screens, identifies and characterizes intact proteins with higher productivity and confidence. The software uses not one, but two deconvolution algorithms to take full advantage of the high-quality, high-resolution accurate mass (HRAM) data produced by Thermo Scientific™ Orbitrap™- based mass spectrometers.

BioPharma Finders peptide mapping workflow confirmation of amino acid sequence, identifies the site and type of expected and unknown PTMS and provides the relative amount of the modification. Additional features include disulfide bond mapping, low level impurity identification (i.e. sequence variants) and sequence alterations such as stress samples in which the software determines the deamidation or oxidation sites and relative abundances. Using the industry-leading, high-resolution, accurate-mass Thermo Scientific™ Orbitrap™ technology with BioPharma Finder software, the most accurate and confident PTM profiles and identifications can be achieved more quickly than ever before.







Related resources


New integrated informatics solution for protein biotherapeutics characterization.

Stephane Houel et al.
Poster Sanibel Conference 2016

ADDITIONAL resources


How to download the software