Most Advanced Mass Spectrometer for the Most Advanced Research Applications
Excel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MS
n analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. This system incorporates the brightest ion source, a segmented quadrupole mass filter with improved selectivity and ion transmission, Advanced Vacuum Technology for improved ion transmission to the Thermo Scientific™ Orbitrap™ mass analyzer, and ETD HD, a higher-capacity ETD fragmentation.
The latest innovations include the Advanced Peak Determination (APD) algorithm for improved data-dependent experiments and two new hardware options: UVPD, a new fragmentation technique achieved with a 213 nm UV laser and 1M, which provides 1,000,000 FWHM ultra-high resolution for improved structural elucidation and quantitation of isobaric compounds.
Check out the latest innovations in Orbitrap Fusion Lumos Technology:
- EASY-IC option for improved mass-to-charge ratio (m/z) assignment
- EASY-ETD option to efficiently fragment peptides and proteins
- UVPD option to fragment the most challenging compounds
- 1,000,000 FWHM ultra-high resolution for in-depth characterization
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Overview of the 1M Option for the Orbitrap Fusion Lumos MS
Comprehensive Characterization of Structurally Diverse Compounds
The Orbitrap Fusion Lumos Tribrid Mass Spectrometer with 1M option offers ultra-high resolution (1,000,000 FWHM at m/z 200) in the highest performance system. The ultra-high resolution along with the versatility of the tribrid platform with unique MS
n capability and a multitude of fragmentation modes allows for comprehensive characterization of expansive range of analytes.
Animation of the Orbitrap Fusion Lumos MS with 1M
Features of the Orbitrap Fusion Lumos MS with 1M
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Customer Testimonials for the 1M option for the Orbitrap Fusion Lumos MS

Dr. Alexander Makarov discusses the ultra-high resolution of the Orbitrap Fusion Lumos with 1M and its use for the structural analysis of small molecules.

Assistant Professor Matthew Mitsche discusses the importance of the 1M option on the Orbitrap Fusion Lumos MS for lipidomics.
Learn about the 1M option at ASMS 2017
Orals
- TOG am 10:10: Extension of Orbitrap Capabilities to Enable New Applications; Alexander Makarov1; Erik Cousijn1; Jesse Canterbury2; Eduard Denisov1; Christian Thoeing1; Oliver Lange1; Arne Kreutzmann1; Konstantin Ayzikov1; Eugen Damoc1; Arrey Tabiwang1; Yue Xuan1; Seema Sharma2; Romain Huguet2; Graeme McAlister2; Mike Senko2; Vlad Zabrouskov2; Alexander Harder1; 1Thermo Fisher Scientific, Bremen, Germany; 2ThermoFisher, San Jose, CA
- MOB am 10:10: Resolution of 13C and Deuterium Isotopes Allows Lipid Fluxomics Analysis By Rate of Deuterium Incorporation; Matthew Mitsche1; Goncalo Vale1; Jeffrey McDonald1; 1University of Texas Southwestern Medical Center, Dallas, TX
- TOB pm 02:50: High Resolution Approaches for the Identification of Environmental Metabolites; Jeffrey Gilbert1; Jesse L. Balcer1; Yelena Adelfinskaya1; David G. McCaskill1; Shusheng Lu1; Kyung Myung1; Pete Johnson1; 1Dow AgroSciences, Indianapolis, IN
Posters
- MP 139: Metabolite Identification of Fentanyl and Fentanyl Analogs Incubated in Human Hepatocytes; Ron G Aoyama1; Tim J. Stratton2; 1Gilead Sciences, Foster City, CA; 2ThermoFisher, San Jose, CA
- MP 643: Multiplex Quantitative Analysis using NeuCode SILAC Metabolic Labeling of Signaling Protein Targets; Ryan Bomgarden1; Kratika Singhal1; Bhavin Patel1; Rosa Viner2; Seema Sharma3; Juergen Cox4; Joshua Coon5; JOHN C. ROGERS1; 1Thermo Fisher Scientific, Rockford, IL; 2Thermo Fisher Scientific, San Jose, CA; 3Thermo Fisher Scientific, San Jose, CA; 4Max Planck Institute of Biochemistry, Martinsried, Germany; 5University of Wisconsin, Madison, WI
- WP 457: Utilizing Very High Resolution for Selective Component Separation in Complex Matrices; Tim Stratton1; Seema Sharma2; 1Thermo Fisher Scientific, San Jose, CA; 2ThermoFisher, San Jose, CA
- ThP 250 Performance Metrics and Example Applications: Orbitrap Mass Spectrometry at Resolving Power 1M; Jesse D. Canterbury1; Seema Sharma2; Tim J. Stratton2; Mike Senko3; Vlad Zabrouskov2; Eduard Denisov4; Alexander Makarov4; 1Thermo Scientific, San Jose, CA; 2Thermo Fisher Scientific, San Jose, CA; 3Thermo Fisher Scientific, San Jose, California; 4Thermo Fisher Scientific, Bremen, Germany
- ThP 362 Ultra High Resolution MS Aids Unknown Extractable Component Identification; Kate Comstock1; Seema Sharma1; Jesse D. Canterbury1; Vlad Zabrouskov1; 1Thermo Fisher Scientific, San Jose, CA