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See the Science of ASMS 2014

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New Library Additions

Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails.

Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G.

J Biol Chem. 2013 Nov 29;288(48):34882-96. doi: 10.1074/jbc.M113.509190. Epub 2013 Oct 15.

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.

Yumimoto K, Matsumoto M, Onoyama I, Imaizumi K, Nakayama KI.

J Biol Chem. 2013 Oct 4;288(40):28488-502. doi: 10.1074/jbc.M113.465179. Epub 2013 Aug 16.

A New In Vivo Cross-linking Mass Spectrometry Platform to Define Protein-Protein Interactions in Living Cells.

Kaake RM, Wang X, Burke A, Yu C, Kandur W, Yang Y, Novtisky EJ, Second T, Duan J, Kao A, Guan S, Vellucci D, Rychnovsky SD, Huang L.

Mol Cell Proteomics. 2014 Sep 24. pii: mcp.M114.042630.

On-the-fly Intact/Topdown Analysis of A Nine Standard Protein Mix Using RP-LC-MS On Q Exactive HF MS

Chen J, Cutak B, Blasberg J, Ray K, Waddell K

PN-64279

CLYBL is a polymorphic human enzyme with malate synthase and b-methylmalate synthase activity

Strittmatter L, Li Y, Nakatsuka NJ, Calvo SE, Grabarek Z, Mootha VK.

Hum Mol Genet. 2014 May 1;23(9):2313-23. doi: 10.1093/hmg/ddt624. Epub 2013 Dec 11.

Elevated S-adenosylhomocysteine alters adipocyte functionality with corresponding changes in gene expression and associated epigenetic marks.

Ngo S, Li X, O'Neill R, Bhoothpur C, Gluckman P, Sheppard A.

Diabetes. 2014 Jul;63(7):2273-83. doi: 10.2337/db13-1640. Epub 2014 Feb 26.

Metabolomics and Mass Isotopomer Analysis as a Strategy for Pathway Discovery: Pyrrolyl and Cyclopentenyl Derivatives of the Pro-Drug of Abuse, Levulinate

Harris SR, Zhang GF, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H.

Chem Res Toxicol. 2013 Feb 18;26(2):213-20. doi: 10.1021/tx3003643. Epub 2012 Dec 6.

Development of LC-MS Methods for Quantitation of Hepcidin and Demonstration of siRNA-Mediated Hepcidin Suppression in Serum

Li S, Nakayama T, Akinc A, Wu SL, Karger BL.

Journal of Pharmacological and Toxicological Methods (2014), doi: 10.1016/j.vascn.2014.09.008

Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4.

Delgoshaie N, Tang X, Kanshin ED, Williams EC, Rudner AD, Thibault P, Tyers M, Verreault A.

J Biol Chem. 2014 May 9;289(19):13186-96. doi: 10.1074/jbc.M113.523530. Epub 2014 Mar 19.

Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics.

Benevento M, Di Palma S, Snijder J, Moyer CL, Reddy VS, Nemerow GR, Heck AJ.

J Biol Chem. 2014 Apr 18;289(16):11421-30. doi: 10.1074/jbc.M113.537498. Epub 2014 Mar 3.

Orbitrap Fusion Tribrid MS

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